Generic name: Aceclofenac
Brand name:
AIRTAL (Highnoon laboratories)
ALKERIS ( Sami pharma)
FLAMIN ( Pulse pharma)
Chemical class: Phenylacetic acid derivative
Therapeutic class: NSAID ; antipyretic; nonnarcotic
analgesic
Dosage form:
Tab 100 mg
Inj 1*5
Indication: Pain and inflammation in rheumatoid arthritis,
osteoarthritis and ankylosing spondylitis.Conditions involving dental and
gynecological pain Symptomatic treatment of pain and inflammation in post
traumatic pain, cervical pain, low-back pain, migraine.
Dose:
By Mouth:
Adult: Maximum recommended dose is 200mg taken as
preparation of 100 mg bid, before or after a meal
Child: Not recommended
By injection:
AdultMaximum recommended dose is 200mg taken as
preparation of 100mg bid, before or after a meal
Child: Not recommended
Contraindication:
Active gastrointestinal bleeding
active gastrointestinal ulceration
cerebrovascular disease-history of gastrointestinal perforation related to previous NSAID therapy
history of
recurrent gastrointestinal hemorrhage (two or more distant episode ).history
of recurrent gastrointestinal ulceration (two or more distinct episode )
ischemic. , Heart disease, mild heart failure, peripheral arterial disease.
Severe heart failure
Cautions: Allergic disorder avoid in acute porphyrias,
cardiac impairment (NSAIDs may impair renal function ). Coagulation defects.
Connective tissue disorders. Crohn’s disease (maybe exacerbated ) elderly
(history of serious side effect and
fatalities) history of cardiac failure hypotension left ventricular
dysfunction, edema, risk factor for cardiovascular events, ulcerative colitis
( maybe exacerbated)
Side effects:
Rare Alveolitis – aseptic meningitis ( patient with
connective- tissue disorders such as systemic lupus erythematosus maybe
especially susceptible) hepatic damage, interstitial fibrosis associated with
NSAIDs can lead to renal failure, pancreatitis, papillary necrosis associated
with NSAIDs can lead to renal failure. Pulmonary eosinophilia, Stevens-
Johnson syndrome.Toxic epidermal necrolysis, visual disturbances
Frequency not known Angioedema, blood disorders,
bronchospasm, colitis (induction od or exacerbation of )
Crohn’s disease ( induction of or exacerbation of )
Depression, drowsiness, fluid retention (Rarely
precipitating congestive heart failure ) gastrointestinal bleeding, gastro
intestinal disturbance,gastro-intestinal ulceration, haematuria, headache,
hearing, disturbances, nervousness, hypersensitivity reactions, insomnia,
nausea, nervousness, photosensitivity, raised blood pressure, rashes, renal
failure (especially in patients with preexisting renal impairment), tinnitus,
vertigo.
Pregnancy: Most manufacturers advise avoiding the use of
NSAIDs during pregnancy
Breast Feeding: Use with caution during breast-feeding
Hepatic Impairment: Initially 100 mg daily. Use with caution;
there is an increased risk of gastrointestinal bleeding and fluid retention.
Avoid in severe liver disease.
Renal impairment: The lowest effective dose should be used
for the shortest possible duration. Avoid if possible or used for the shortest
possible duration. Avoid if possible or use with caution, avoid in moderate to
severe impairment.
In Real impairment monitor renal function; sodium and water
retention may occur and renal function may deteriorate, possibly leading to
renal failure.
