Genric Name: Zafirlukast
Brand Name:
XASTHMA (Safe)
Z-KAST (Lowitt)
ZUKAST (Everest)
Chemical class:
Tolysulfonyl Benzamide derivatives
Therapeutic class:
Antiasthmatic, leukotriene receptors antagonist
Indications and dose:
Prophylaxis of asthma
Child: 12-17 years:
20 mg twice daily
Adult: 20 mg twice daily
Cautions: Elderly
Pregnancy and lactations:
Pregnancy category C, breast milk excretion unknown
Side effects/Adverse reactions::
CNS: Headache (18%), somnolence, weakness
EENT: Pharyngitis (20%), rhinitis (9%)
GI: Dry mouth, elevated transaminase levels, gastritis
RESP: Cough, exacerbation of asthma
Interaction:
Drugs:
Astemizole, teifenadine L Zafirlukast inhibits drug
metabolism with potential for cardiac dysrhythmias Warfarin: Zafirlukast
increases hypoprothrombinemia effect
