Genric Name: Valdecoxib
Brand Name:
NOVICOXIB (Novins)
Chemical class:
Cycloxygenase-2 (COX-2 inhibitors)
Therapeutic class
COX-2 specific inhibitor, NSAID, Non-Narcotic analgesic
Dosage form:
Tab 20 mg
Indication and Dosage:
Adult and Child > 16 yr
Osteoarthritis. rheumatoid arthritis
PO 10 mg qd
Dysmenorrhea
PO 20-40 mg qd or 20 mg bid
Pain
PO 20-40 mg qd
Renal Hepatic Dysfunction:
No change in dose in renal failure, significant increases
(130% ) in valdecoxib levels seen in moderate liver dysfunction, don’t exceed
10 mg qd with close monitoring for edema, avoid in patients with severe liver
dysfunction
Contraindications:
Hypersensitivity, allergic to sulfa containing product, patients who have experienced asthma, urticaria, or allergic-type reactions with aspirin or other NSAIDs (aspirin triad) , acute peptic ulcer disease, or GI bleeding, severe hepatic or renal disease
Precautions.
History of GI ulceration, concomitant treatment with oral corticosteroids, anticoagulants, smokers, alcoholism, older age, stress, or poor general health status ( increased risk for GI ulceration, bleeding, or perforation ), mild or moderate renal and liver dysfunction, concurrent disease increases the risk for renal dysfunction (i.e. diabetes, preexisting edema , hypovolemia, sepsis ), pregnancy ( 1st and 3rd trimesters) , CHF, elderly, concurrent diuretics, and ACE inhibitors, hypertension
Pregnancy and Lactations:
Pregnancy category C, excreted into breast milk of animals
Side effects/Adverse reactions
CNS: Dizziness, headache
EENT: Sinusitis
GI: Nausea, Dyspepsia, abdominal pain , abdominal fullness,
diarrhea
GU: Serum creatinine, BUN Increase
HEME: Anemia
MS: Back pain, myalgia
RESP: Upper respiratory tract infection
SKIN: Rash, Steven’s Johnsons syndrome
Interactions:
Drugs:
Angiotensin-converting enzyme inhibitors: Diminished
antihypertensive effects
Aspirin: Increased risk of GI ulceration, the negation of
cardioprotective effects of aspirin
Diuretic (loop, thiazide) Reduced naturetic effect
Lithium: Elevation of plasma lithium levels, potential
lithium toxicity
