Genric name: Bacampicillin
Brand name: PROGLOBE ( Barrett Hodgson )
Dosage form:
Tabs 400 mg
DS Tabs 800 mg
Indication
Infections of the upper and lower respiratory tract, including acute exacerbations of chronic bronchitis,
Skin and skin structure
Urinary tract infections
Gonorrhea (acute uncomplicated urogenital
infections ) due to susceptible organisms.
DOSE
Adult: Usual dosage PO 400-800 mg q12h.
Gonorrhea (acute uncomplicated urogenital infections due to
N, gonorrhea, males and females) 1.6mg ( 4*400 mg tablets plus 1 g ) as a
single oral dose.
Child: Usual dosage PO 25-5- mg/ kg/day in divided doses q
12h
Contraindication:
Hypersensitivity to penicillins.
Precautions:
Superinfections with mycotic or bacterial pathogens,
concomitant mononucleosis ( high percentage develop a skin rash)
Pregnancy and lactation:
Excreted in milk: milk: plasma ratio up to 0.2
Side effects
CNS: Anxiety, coma, depression, hallucination, lethargy,
seizures, twitching
GI: Black “hairy” tongue, diarrhea, enterocolitis gastritis
, glossitis, increased AST/ALT, nausea pseudomembranous colitis, stomatitis,
vomiting
GU: Glomerulonepritis , hematuria, monilasis, oliguria, proteinuria,
vaginitis
HEME: Anemia, bone marrow depression, granulocytopenia,
increased, thrombocytopenic purpura, thrombocytopenia, eosinophilia,
leukopenia, and agranulocytosis ( hypersensitivity phenomena)
MISC: Hypersensitivity reactions ( skin rashes, urticarial,
erythema, multiform, and an occasional case of exfoliative dermatitis, skin
rash when given with allopurinol) serious, and occasionally fatal
hypersensitivity ( anaphylactic)
Interactions:
Drugs:
Atenolol: reduced serum concentration of atenolol
Chloramphenicol: inhibited antibacterial activity of bacampicillin; administer
bacampicillin 3 hours before chloramphenicol
Macrolide antibiotics: inhibited antibacterial activity of
bacampicillin: administer bacampicillin 3 hours before macrolides
Methotrexate: Occasional impairment of oral contraceptive
efficacy: consider use of supplemental contraception during cycles in which
bacampicillin is used
Tetracyclines: inhibited antibacterial activity of
bacampicillin; administer bacampicillin in 3 hours before tetracycline.s
