Genric Name: Zoledronic Acid
Brand Name:
ACLASTA (Novartis)
EDONAX (S.J. & G Fazul Ellahie)
KEDRONICO (Oncogene)
Madronic (Macter)
ZOLEDRONIC (Al-Habib Pharma)
ZOLDRIA (A.J. Mirza Pharma)
ZOMETA (Novartis)
Chemical class:
Bisphosphoric acid
Therapeutic class:
Bisophasphate, bone resorption inhibitors
Dosage form:
Inj 5mg/100 ml
Indications:
Tumor-induced hypocalcemia of malignancy
Paget’s diseases of bone
Osteolytic bone metastases.
Dose:
Adult: 4 mg reconstituted and diluted for infusion with 50
ml of 0.9% w/v saline or 5% w/v glucose solution, given as a single 15 minute intravenous
infusion
Children: Not recommended
Contraindications:
Hypersensitivity to bisphosphonates, pregnancy, and lactation
Side effects/Adverse reactions:
Severe renal or hepatic impairment.
Cardiac failure
Monitor serum calcium phosphate and magnesium levels
Monitor renal function
Heme: Abdominal pain, anorexia, constipation, diarrhea,
dysphagia,nausea, vomiting
